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For more information concerning the use of Itraconazole in cystic fibrosis patients see the prescribing information for Itraconazole oral solution. Transient or permanent hearing loss has been reported in patients receiving treatment with Itraconazole. The hearing loss usually resolves when treatment is stopped, but can persist in some patients. Effect of Itraconazole Capsules on Other Drugs. Itraconazole is an inhibitor of the drug transporters P-glycoprotein and breast cancer resistance protein BCRP. Consequently, Itraconazole has the potential to interact with many concomitant drugs resulting in either increased or sometimes decreased concentrations of the concomitant drugs. Increased emotional health issues may increase the risk of adverse reactions associated with the concomitant drug which can be severe or life-threatening in some cases e. Reduced concentrations of concomitant drugs may Erectile Dysfunction causes their efficacy. Table 1 lists examples of drugs that may have their concentrations affected by Itraconazole, but is not a comprehensive list. Refer to the approved product labeling to become familiar with the interaction pathways, risk potential, and specific actions to be taken with regards to each concomitant drug prior to initiating therapy with Itraconazole. Although many of the clinical drug interactions in Table 1 are based on information with a similar azole antifungal, ketoconazole, these interactions are expected to occur with Itraconazole.

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